Natural Skincare vs. Regular??????

Well in the past I have wanted to try more natural products, but most if not all of them have cause some kind of irritation to my skin. In all honesty I haven't tried too many products. What drugstore brands are good? What kind of ingredients should I look for for combo/sensitive skin with some acne?

P.S. Is it ok to switch up Skincare Products a lot (like everytime something runs out) or should I wait to switch even if I don't like something?

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